› 7vy0

Electron Microscopy
2.7Å resolution

Coxsackievirus B3 full particle at pH7.4 (VP3-234N)

Released:
DOI: 10.2210/pdb7vy0/pdb
PDB entry 7vy0 coloured by chain, front view.
PDB entry 7vy0 coloured by chain, side view.
PDB entry 7vy0 coloured by chain, top view.
Source organism: Coxsackievirus B3
Primary publication:
Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains.
Wang Q, Yang Q, Liu C, Wang G, Song H, Shang G, Peng R, Qu X, Liu S, Cui Y, Wang P, Xu W, Zhao X, Qi J, Yang M, Gao GF
Proc Natl Acad Sci U S A 119 (2022)
PMID: 35046043
Related structures: EMD-32190

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136773 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 284 amino acids
Theoretical weight: 31.7 KDa
Source organism: Coxsackievirus B3
Expression system: Homo sapiens
UniProt:
  • Canonical: P03313 (Residues: 571-854; Coverage: 13%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 263 amino acids
Theoretical weight: 28.86 KDa
Source organism: Coxsackievirus B3
Expression system: Homo sapiens
UniProt:
  • Canonical: P03313 (Residues: 70-332; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 26.13 KDa
Source organism: Coxsackievirus B3
Expression system: Homo sapiens
UniProt:
  • Canonical: P03313 (Residues: 333-570; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 69 amino acids
Theoretical weight: 7.44 KDa
Source organism: Coxsackievirus B3
Expression system: Homo sapiens
UniProt:
  • Canonical: P03313 (Residues: 1-69; Coverage: 3%)
Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

1 bound ligand:
Ligand PLM 1 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-32190
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Chen et al. (2022)