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Matrix arm of deactive state CI from Q10-NADH dataset

Source organism: Sus scrofa
Biochemical function: oxidoreductase activity, acting on NAD(P)H
Biological process: ATP synthesis coupled electron transport
Cellular component: mitochondrion

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EC 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating)

Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Systematic name:
NADH:ubiquinone oxidoreductase
Alternative Name(s):
  • Coenzyme Q reductase
  • Complex 1 dehydrogenase
  • Complex I (NADH:Q1 oxidoreductase)
  • Complex I (electron transport chain)
  • Complex I (mitochondrial electron transport)
  • DPNH-coenzyme Q reductase
  • DPNH-ubiquinone reductase
  • Dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
  • Electron transfer complex I
  • Mitochondrial electron transport complex 1
  • Mitochondrial electron transport complex I
  • NADH coenzyme Q1 reductase
  • NADH dehydrogenase (ubiquinone)
  • NADH-CoQ oxidoreductase
  • NADH-CoQ reductase
  • NADH-Q6 oxidoreductase
  • NADH-coenzyme Q oxidoreductase
  • NADH-coenzyme Q reductase
  • NADH-ubiquinone oxidoreductase
  • NADH-ubiquinone reductase
  • NADH-ubiquinone-1 reductase
  • NADH:ubiquinone oxidoreductase complex
  • Reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
  • Type 1 dehydrogenase
  • Ubiquinone reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF10276
Domain description: Zinc-finger domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF10276 (Zinc-finger domain) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial. Showing 1 copy in chain Q [auth T].

PF00346
Domain description: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF00346 (Respiratory-chain NADH dehydrogenase, 49 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial. Showing 1 copy in chain P [auth Q].

PF00329
Domain description: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF00329 (Respiratory-chain NADH dehydrogenase, 30 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial. Showing 1 copy in chain O [auth P].

PF01257
Domain description: Thioredoxin-like [2Fe-2S] ferredoxin
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial. Showing 1 copy in chain N [auth O].

PF05071
Domain description: NADH ubiquinone oxidoreductase subunit NDUFA12
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF05071 (NADH ubiquinone oxidoreductase subunit NDUFA12) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12. Showing 1 copy in chain M [auth N].

PF09326
Domain description: NADH-ubiquinone oxidoreductase subunit G, C-terminal
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF09326 (NADH-ubiquinone oxidoreductase subunit G, C-terminal) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain L [auth M].

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain L [auth M].

PF22151
Domain description: NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

PF22117
Domain description: NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

PF10588
Domain description: NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain L [auth M].

PF13510
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF13510 (2Fe-2S iron-sulfur cluster binding domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain L [auth M].

PF04800
Domain description: NADH dehydrogenase ubiquinone Fe-S protein 4
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF04800 (NADH dehydrogenase ubiquinone Fe-S protein 4) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. Showing 1 copy in chain K [auth L].

PF15880
Domain description: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF15880 (NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial) in NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial. Showing 1 copy in chain J [auth K].

PF01370
Domain description: NAD dependent epimerase/dehydratase family
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF01370 (NAD dependent epimerase/dehydratase family) in NAD-dependent epimerase/dehydratase domain-containing protein. Showing 1 copy in chain I [auth J].

PF07347
Domain description: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF07347 (NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7. Showing 1 copy in chain H [auth I].

PF04716
Domain description: ETC complex I subunit conserved region
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF04716 (ETC complex I subunit conserved region) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5. Showing 1 copy in chain G [auth H].

PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF00550 (Phosphopantetheine attachment site) in Acyl carrier protein. Showing 1 copy in chain F [auth G].

PF05047
Domain description: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF05047 (Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2. Showing 1 copy in chain E [auth F].

PF05347
Domain description: Complex 1 protein (LYR family)
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF05347 (Complex 1 protein (LYR family)) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6. Showing 1 copy in chain D [auth E].

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial. Showing 1 copy in chain C.

PF12838
Domain description: 4Fe-4S dicluster domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF12838 (4Fe-4S dicluster domain) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial. Showing 1 copy in chain B.

PF10589
Domain description: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain A.

PF22461
Domain description: SLBB domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

PF01512
Domain description: Respiratory-chain NADH dehydrogenase 51 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
The deposited structure of PDB entry 7vya contains 1 copy of Pfam domain PF01512 (Respiratory-chain NADH dehydrogenase 51 Kd subunit) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002023
Domain description: NADH-quinone oxidoreductase subunit E-like
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
IPR019574
Domain description: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR000283
Domain description: NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR003231
Domain description: Acyl carrier protein
Occurring in:
  1. Acyl carrier protein
IPR006138
Domain description: NADH-ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
IPR010226
Domain description: NADH-quinone oxidoreductase, chain I
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
IPR029014
Domain description: [NiFe]-hydrogenase, large subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
IPR022885
Domain description: NAD(P)H-quinone oxidoreductase subunit D/H
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
IPR010218
Domain description: NADH dehydrogenase, subunit C
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
IPR037232
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
IPR007763
Domain description: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR006885
Domain description: NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
IPR026193
Domain description: NADH-ubiquinone oxidoreductase flavoprotein 3
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
IPR009947
Domain description: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
IPR006806
Domain description: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
IPR009081
Domain description: Phosphopantetheine binding ACP domain
Occurring in:
  1. Acyl carrier protein
IPR036736
Domain description: ACP-like superfamily
Occurring in:
  1. Acyl carrier protein
IPR007741
Domain description: Ribosomal protein/NADH dehydrogenase domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
  2. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
IPR016464
Domain description: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
IPR016488
Domain description: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
IPR019575
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
IPR037207
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
IPR001949
Domain description: NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
IPR037225
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
IPR009346
Domain description: GRIM-19
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
IPR019401
Domain description: Zinc finger, CHCC-type
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
IPR016668
Domain description: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
IPR001135
Domain description: NADH-quinone oxidoreductase, subunit D
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
IPR014029
Domain description: NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
IPR020396
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
IPR001268
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
IPR042128
Domain description: NuoE domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
IPR041921
Domain description: NADH-quinone oxidoreductase subunit E, N-terminal
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
IPR015405
Domain description: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR006656
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR006963
Domain description: Molybdopterin oxidoreductase, 4Fe-4S domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR010228
Domain description: NADH:ubiquinone oxidoreductase, subunit G
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
IPR038532
Domain description: NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
IPR001509
Domain description: NAD-dependent epimerase/dehydratase
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
IPR006162
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein
IPR008011
Domain description: Complex 1 LYR protein domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
IPR045299
Domain description: NDUFA6, LYR domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
IPR006137
Domain description: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
IPR011538
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
IPR011537
Domain description: NADH ubiquinone oxidoreductase, F subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

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