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Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1

Electron Microscopy
3.59Å resolution
PDB entry 7vzb coloured by chain, front view.
PDB entry 7vzb coloured by chain, side view.
PDB entry 7vzb coloured by chain, top view.
Source organisms:
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ABC transporter domain-containing protein, ATP-binding cassette sub-family D member 1
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Multimeric state: homo dimer
Accessible surface area: 56880.38 Å2
Buried surface area: 12148.08 Å2
Dissociation area: 6,074.04 Å2
Dissociation energy (ΔGdiss): 80.57 kcal/mol
Dissociation entropy (TΔSdiss): 17.01 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-129205

Macromolecules

ABC transporter domain-containing protein; ATP-binding cassette sub-family D member 1
Chains: A, B
Length: 789 amino acids
Theoretical weight: 87.93 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: O45730 (Residues: 2-66; Coverage: 9%)
  • Canonical: P33897 (Residues: 65-745; Coverage: 91%)
    • nullnull
Gene names: ABCD1, ALD, CELE_T02D1.5, T02D1.5, pmp-4
Pfam:
InterPro:
ABC transporter domain-containing protein in PDB entry 7vzb, assembly 1, front view.
ABC transporter domain-containing protein in PDB entry 7vzb, assembly 1, side view.
ABC transporter domain-containing protein in PDB entry 7vzb, assembly 1, top view.
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