7w0a

Electron Microscopy
3.12Å resolution

dmDicer2-LoqsPD-dsRNA Dimer status

Released:
Source organism: Drosophila melanogaster
Related structures: EMD-32236

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-499774 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct RNA molecules
Macromolecules (4 distinct):
Endoribonuclease Dcr-2 Chains: A, E
Molecule details ›
Chains: A, E
Length: 1722 amino acids
Theoretical weight: 198.01 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A1ZAW0 (Residues: 1-1722; Coverage: 100%)
Gene names: CG6493, Dcr-2, Dicer2, dcr, dic2
Sequence domains:
Protein Loquacious Chains: B, F
Molecule details ›
Chains: B, F
Length: 359 amino acids
Theoretical weight: 38.5 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9VJY9 (Residues: 1-337; Coverage: 73%)
  • Best match: Q9VJY9-4 (Residues: 1-359)
Gene names: CG6866, TRBP, dRax, loq, loqs, r3d1
Sequence domains: Double-stranded RNA binding motif
RNA (30-MER) Chains: C, G
Molecule details ›
Chains: C, G
Length: 31 nucleotides
Theoretical weight: 10.01 KDa
RNA (32-MER) Chains: D, H
Molecule details ›
Chains: D, H
Length: 32 nucleotides
Theoretical weight: 10.14 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-32236
Expression system: Spodoptera frugiperda