Function and Biology

dmDicer2-LoqsPD-dsRNA Dimer status

Source organism: Drosophila melanogaster
Biochemical function: siRNA binding
Biological process: lncRNA catabolic process
Cellular component: RISC-loading complex

EC 3.1.26.3: Ribonuclease III

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Systematic name:
-
Alternative Name(s):
  • RNase III
  • Ribonuclease 3

Sequence families

Pfam Protein families (Pfam)
PF00035
Domain description: Double-stranded RNA binding motif
Occurring in:
  1. Endoribonuclease Dcr-2
  2. Protein Loquacious
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF00035 (Double-stranded RNA binding motif) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 7w0a contains 4 copies of Pfam domain PF00035 (Double-stranded RNA binding motif) in Protein Loquacious. Showing 2 copies in chain B (this domain is out of the observed residue ranges!).

PF00636
Domain description: Ribonuclease III domain
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 4 copies of Pfam domain PF00636 (Ribonuclease III domain) in Endoribonuclease Dcr-2. Showing 2 copies in chain A.

PF02170
Domain description: PAZ domain
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF02170 (PAZ domain) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.

PF20931
Domain description: Dicer, platform domain
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF20931 (Dicer, platform domain) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.

PF03368
Domain description: Dicer dimerisation domain
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF03368 (Dicer dimerisation domain) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.

PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.

PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. Endoribonuclease Dcr-2
The deposited structure of PDB entry 7w0a contains 2 copies of Pfam domain PF00270 (DEAD/DEAH box helicase) in Endoribonuclease Dcr-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014720
Domain description: Double-stranded RNA-binding domain
Occurring in:
  1. Endoribonuclease Dcr-2
  2. Protein Loquacious
IPR000999
Domain description: Ribonuclease III domain
Occurring in:
  1. Endoribonuclease Dcr-2
IPR036389
Domain description: Ribonuclease III, endonuclease domain superfamily
Occurring in:
  1. Endoribonuclease Dcr-2
IPR003100
Domain description: PAZ domain
Occurring in:
  1. Endoribonuclease Dcr-2
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. Endoribonuclease Dcr-2
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Endoribonuclease Dcr-2
IPR005034
Domain description: Dicer dimerisation domain
Occurring in:
  1. Endoribonuclease Dcr-2
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Endoribonuclease Dcr-2
IPR038248
Domain description: Dicer dimerisation domain superfamily
Occurring in:
  1. Endoribonuclease Dcr-2
IPR011545
Domain description: DEAD/DEAH box helicase domain
Occurring in:
  1. Endoribonuclease Dcr-2