7w2b

X-ray diffraction
3.2Å resolution

The closed conformation of the sigma-1 receptor from Xenopus laevis

Released:
Source organism: Xenopus laevis

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
PDBe Complex ID:
PDB-CPX-563707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sigma non-opioid intracellular receptor 1 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 225 amino acids
Theoretical weight: 25.12 KDa
Source organism: Xenopus laevis
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q6DCU6 (Residues: 1-221; Coverage: 100%)
Gene names: oprs1, sigmar1
Sequence domains: ERG2 and Sigma1 receptor like protein

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 86.718Å b: 148.45Å c: 172.137Å
α: 90° β: 92.44° γ: 90°
R-values:
R R work R free
0.242 0.241 0.269
Expression system: Komagataella pastoris