Function and Biology Details
Reactions catalysed:
Cleavage of peptide bonds with very broad specificity.
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero 49-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100675 (preferred)
Entry contents:
35 distinct polypeptide molecules
Macromolecules (35 distinct):
26S proteasome regulatory subunit 7
Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 433 amino acids
Theoretical weight: 48.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome regulatory subunit 4
Chain: B
Molecule details ›
Chain: B
Length: 440 amino acids
Theoretical weight: 49.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 440 amino acids
Theoretical weight: 49.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome regulatory subunit 8
Chain: C
Molecule details ›
Chain: C
Length: 398 amino acids
Theoretical weight: 44.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 398 amino acids
Theoretical weight: 44.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome regulatory subunit 6B
Chain: D
Molecule details ›
Chain: D
Length: 418 amino acids
Theoretical weight: 47.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 418 amino acids
Theoretical weight: 47.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
AAA+ ATPase domain-containing protein
Chain: E
Molecule details ›
Chain: E
Length: 403 amino acids
Theoretical weight: 45.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 403 amino acids
Theoretical weight: 45.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome regulatory subunit 6A
Chain: F
Molecule details ›
Chain: F
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 439 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-6
Chains: G, g
Molecule details ›
Chains: G, g
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-2
Chains: H, h
Molecule details ›
Chains: H, h
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-4
Chains: I, i
Molecule details ›
Chains: I, i
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-7
Chains: J, j
Molecule details ›
Chains: J, j
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-5
Chains: K, k
Molecule details ›
Chains: K, k
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-1
Chains: L, l
Molecule details ›
Chains: L, l
Length: 269 amino acids
Theoretical weight: 30.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 269 amino acids
Theoretical weight: 30.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit alpha type-3
Chains: M, m
Molecule details ›
Chains: M, m
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-6
Chains: N, n
Molecule details ›
Chains: N, n
Length: 239 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 239 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-7
Chains: O, o
Molecule details ›
Chains: O, o
Length: 277 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 277 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-3
Chains: P, p
Molecule details ›
Chains: P, p
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-2
Chains: Q, q
Molecule details ›
Chains: Q, q
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-5
Chains: R, r
Molecule details ›
Chains: R, r
Length: 263 amino acids
Theoretical weight: 28.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 263 amino acids
Theoretical weight: 28.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-1
Chains: S, s
Molecule details ›
Chains: S, s
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Proteasome subunit beta type-4
Chains: T, t
Molecule details ›
Chains: T, t
Length: 264 amino acids
Theoretical weight: 29.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 264 amino acids
Theoretical weight: 29.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 1
Chain: U
Molecule details ›
Chain: U
Length: 953 amino acids
Theoretical weight: 105.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 953 amino acids
Theoretical weight: 105.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 11
Chain: X
Molecule details ›
Chain: X
Length: 422 amino acids
Theoretical weight: 47.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 422 amino acids
Theoretical weight: 47.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 6
Chain: Y
Molecule details ›
Chain: Y
Length: 389 amino acids
Theoretical weight: 45.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 389 amino acids
Theoretical weight: 45.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 7
Chain: Z
Molecule details ›
Chain: Z
Length: 324 amino acids
Theoretical weight: 37.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 324 amino acids
Theoretical weight: 37.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 13
Chain: a
Molecule details ›
Chain: a
Length: 376 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 376 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 4
Chain: b
Molecule details ›
Chain: b
Length: 377 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 377 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 14
Chain: c
Molecule details ›
Chain: c
Length: 310 amino acids
Theoretical weight: 34.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 310 amino acids
Theoretical weight: 34.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 8
Chain: d
Molecule details ›
Chain: d
Length: 350 amino acids
Theoretical weight: 39.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 350 amino acids
Theoretical weight: 39.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome non-ATPase regulatory subunit 2
Chain: f
Molecule details ›
Chain: f
Length: 908 amino acids
Theoretical weight: 100.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 908 amino acids
Theoretical weight: 100.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 14
Chain: x
Molecule details ›
Chain: x
Length: 494 amino acids
Theoretical weight: 56.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Length: 494 amino acids
Theoretical weight: 56.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Ubiquitin
Chain: y
Molecule details ›
Chain: y
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
26S proteasome non-ATPase regulatory subunit 12
Chain: W
Molecule details ›
Chain: W
Length: 456 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 456 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Substrate
Chain: v
Molecule details ›
Chain: v
Length: 34 amino acids
Theoretical weight: 2.91 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
Length: 34 amino acids
Theoretical weight: 2.91 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
26S proteasome non-ATPase regulatory subunit 3
Chain: V
Molecule details ›
Chain: V
Length: 534 amino acids
Theoretical weight: 61.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 534 amino acids
Theoretical weight: 61.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
26S proteasome complex subunit SEM1
Chain: e
Molecule details ›
Chain: e
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 70 amino acids
Theoretical weight: 8.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens