› 7w7v

Electron Microscopy
3Å resolution

'late' E2P of SERCA2b

Released:
DOI: 10.2210/pdb7w7v/pdb
PDB entry 7w7v coloured by chain, front view.
PDB entry 7w7v coloured by chain, side view.
PDB entry 7w7v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multiple sub-state structures of SERCA2b reveal conformational overlap at transition steps during the catalytic cycle.
Zhang Y, Kobayashi C, Cai X, Watanabe S, Tsutsumi A, Kikkawa M, Sugita Y, Inaba K
Cell Rep 41 111760 (2022)
PMID: 36476867
Related structures: EMD-32349

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 1042 amino acids
Theoretical weight: 114.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16615 (Residues: 1-1042; Coverage: 100%)
Gene names: ATP2A2, ATP2B
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand BEF 1 x BEF
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-32349
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus.
Chen et al. (2023)
2 more