Function and Biology

Crystal Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 (P450BM3) Heme Domain with N-Hexadecanoyl-L-Homoserine

Source organism: Priestia megaterium
Biochemical function: heme binding
Biological process: not assigned
Cellular component: not assigned

EC 1.6.2.4: NADPH--hemoprotein reductase

Reaction catalysed:
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein
Systematic name:
NADPH:hemoprotein oxidoreductase
Alternative Name(s):
  • Aldehyde reductase (NADPH-dependent)
  • CPR
  • Cytochrome P-450 reductase
  • Cytochrome P450 reductase
  • Cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
  • Dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
  • FAD-cytochrome c reductase
  • Ferrihemoprotein P-450 reductase
  • NADP--cytochrome c reductase
  • NADP--cytochrome reductase
  • NADPH--cytochrome P-450 oxidoreductase
  • NADPH--cytochrome P450 oxidoreductase
  • NADPH--cytochrome P450 reductase
  • NADPH--cytochrome c oxidoreductase
  • NADPH--cytochrome c reductase
  • NADPH--cytochrome p-450 reductase
  • NADPH--ferricytochrome c oxidoreductase
  • NADPH--ferrihemoprotein reductase
  • NADPH-dependent cytochrome c reductase
  • NADPH:P-450 reductase
  • NADPH:P450 reductase
  • NADPH:ferrihemoprotein oxidoreductase
  • POR
  • Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
  • Reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
  • TPNH(2) cytochrome c reductase
  • TPNH-cytochrome c reductase

EC 1.14.14.1: Unspecific monooxygenase

Reaction catalysed:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
Systematic name:
Substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Alternative Name(s):
  • Aryl hydrocarbon hydroxylase
  • Aryl-4-monooxygenase
  • Cytochrome P450
  • Flavoprotein monooxygenase
  • Flavoprotein-linked monooxygenase
  • Microsomal P-450
  • Microsomal P450
  • Microsomal monooxygenase
  • Xenobiotic monooxygenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Bifunctional cytochrome P450/NADPH--P450 reductase
The deposited structure of PDB entry 7w9d contains 2 copies of Pfam domain PF00067 (Cytochrome P450) in Bifunctional cytochrome P450/NADPH--P450 reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Bifunctional cytochrome P450/NADPH--P450 reductase
IPR002401
Domain description: Cytochrome P450, E-class, group I
Occurring in:
  1. Bifunctional cytochrome P450/NADPH--P450 reductase
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Bifunctional cytochrome P450/NADPH--P450 reductase
IPR017972
Domain description: Cytochrome P450, conserved site
Occurring in:
  1. Bifunctional cytochrome P450/NADPH--P450 reductase