› 7wa9

X-ray diffraction
1.9Å resolution

Crystal structure of MSMEG_5634 from Mycobacterium smegmatis

Released:
DOI: 10.2210/pdb7wa9/pdb
PDB entry 7wa9 coloured by chain, front view.
PDB entry 7wa9 coloured by chain, side view.
PDB entry 7wa9 coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis.
Li M, Huang Q, Zhang W, Cao Y, Wang Z, Zhao Z, Zhang X, Zhang J
OpenAccess logo Front Microbiol 13 846722 (2022)
PMID: 35444621

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106450 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toxin Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.41 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0R3Y0 (Residues: 1-147; Coverage: 100%)
Gene name: MSMEG_5634
Sequence domains: Polyketide cyclase / dehydrase and lipid transport

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 71.072Å b: 55.011Å c: 40.733Å
α: 90° β: 112.754° γ: 90°
R-values:
R R work R free
0.236 0.233 0.282
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The Role of Phosphorylation and Acylation in the Regulation of Drug Resistance in Mycobacterium tuberculosis.
Sun et al. (2022)
2 more

1 mention without citation

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis.
Li et al. (2022)