› 7wbu

Electron Microscopy
3.42Å resolution

Cryo-EM structure of bovine NLRP9

Released:
DOI: 10.2210/pdb7wbu/pdb
PDB entry 7wbu coloured by chain, front view.
PDB entry 7wbu coloured by chain, side view.
PDB entry 7wbu coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Kamitsukasa Y, Nakano K, Murakami K, Hirata K, Yamamoto M, Shimizu T, Ohto U
FEBS Lett 596 876-885 (2022)
PMID: 35090055
Related structures: EMD-32406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-557701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 932 amino acids
Theoretical weight: 106.63 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q288C4 (Residues: 89-996; Coverage: 91%)
Gene names: NALP9, NLRP9
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.42Å
Relevant EMDB volumes: EMD-32406
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Activation and regulation mechanisms of NOD-like receptors based on structural biology.
Ohto U. (2022)
1 other article