› 7weg

X-ray diffraction
2Å resolution

Complex structure of PDZD7 and FCHSD2

Released:
DOI: 10.2210/pdb7weg/pdb
PDB entry 7weg coloured by chain, front view.
PDB entry 7weg coloured by chain, side view.
PDB entry 7weg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2.
Wang H, Zhao D, Du H, Zhai X, Wu S, Lin L, Xu Z, Lu Q
OpenAccess logo Biochem J 479 1393-1405 (2022)
PMID: 35695292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-221128 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PDZ domain-containing protein 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: E9Q9W7 (Residues: 842-946; Coverage: 10%)
Gene name: Pdzd7
Sequence domains: PDZ domain
F-BAR and double SH3 domains protein 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3USJ8 (Residues: 728-740; Coverage: 2%)
Gene names: Fchsd2, Kiaa0769, Sh3md3

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 41.603Å b: 62.918Å c: 46.03Å
α: 90° β: 95.19° γ: 90°
R-values:
R R work R free
0.214 0.209 0.256
Expression system: Escherichia coli BL21(DE3)

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