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Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase in complex with GTP

Source organism: Leishmania donovani
Biochemical function: transferase activity
Biological process: GDP-mannose biosynthetic process
Cellular component: cytoplasm

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EC 2.7.7.13: Mannose-1-phosphate guanylyltransferase

Reaction catalysed:
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
Systematic name:
GTP:alpha-D-mannose-1-phosphate guanylyltransferase
Alternative Name(s):
  • GDP-mannose pyrophosphorylase
  • GTP-mannose-1-phosphate guanylyltransferase
  • Guanosine 5'-diphospho-D-mannose pyrophosphorylase
  • Guanosine diphosphomannose pyrophosphorylase
  • Guanosine triphosphate-mannose 1-phosphate guanylyltransferase
  • Mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
  • PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00132
Domain description: Bacterial transferase hexapeptide (six repeats)
Occurring in:
  1. mannose-1-phosphate guanylyltransferase
The deposited structure of PDB entry 7whs contains 6 copies of Pfam domain PF00132 (Bacterial transferase hexapeptide (six repeats)) in mannose-1-phosphate guanylyltransferase. Showing 1 copy in chain A.

PF00483
Domain description: Nucleotidyl transferase
Occurring in:
  1. mannose-1-phosphate guanylyltransferase
The deposited structure of PDB entry 7whs contains 6 copies of Pfam domain PF00483 (Nucleotidyl transferase) in mannose-1-phosphate guanylyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. mannose-1-phosphate guanylyltransferase
IPR001451
Domain description: Hexapeptide repeat
Occurring in:
  1. mannose-1-phosphate guanylyltransferase
IPR005835
Domain description: Nucleotidyl transferase domain
Occurring in:
  1. mannose-1-phosphate guanylyltransferase
IPR045233
Domain description: Mannose-1-phosphate guanyltransferase, N-terminal domain
Occurring in:
  1. mannose-1-phosphate guanylyltransferase

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