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Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: ABC-type transporter activity
Biological process: transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
The deposited structure of PDB entry 7wiw contains 1 copy of Pfam domain PF00005 (ABC transporter) in Mycobactin import ATP-binding/permease protein IrtB. Showing 1 copy in chain A [auth B].
The deposited structure of PDB entry 7wiw contains 1 copy of Pfam domain PF00005 (ABC transporter) in Mycobactin import ATP-binding/permease protein IrtA. Showing 1 copy in chain B [auth A].

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
The deposited structure of PDB entry 7wiw contains 1 copy of Pfam domain PF00664 (ABC transporter transmembrane region) in Mycobactin import ATP-binding/permease protein IrtA. Showing 1 copy in chain B [auth A].

PF04954
Domain description: Siderophore-interacting protein
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
The deposited structure of PDB entry 7wiw contains 1 copy of Pfam domain PF04954 (Siderophore-interacting protein) in Mycobactin import ATP-binding/permease protein IrtA. Showing 1 copy in chain B [auth A] (this domain is out of the observed residue ranges!).

PF08021
Domain description: Siderophore-interacting FAD-binding domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
The deposited structure of PDB entry 7wiw contains 1 copy of Pfam domain PF08021 (Siderophore-interacting FAD-binding domain) in Mycobactin import ATP-binding/permease protein IrtA. Showing 1 copy in chain B [auth A] (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR039421
Domain description: Type 1 protein exporter
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
  2. Mycobactin import ATP-binding/permease protein IrtB
IPR007037
Domain description: Siderophore-interacting protein, C-terminal domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
IPR039261
Domain description: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
IPR013113
Domain description: FAD-binding 9, siderophore-interacting
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
IPR017927
Domain description: FAD-binding domain, ferredoxin reductase-type
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA
IPR017938
Domain description: Riboflavin synthase-like beta-barrel
Occurring in:
  1. Mycobactin import ATP-binding/permease protein IrtA

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