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Cryo-EM structure of SARS-CoV-2 Omicron spike protein with human ACE2 (focus refinement on RBD-1/ACE2)

Source organisms:
Biochemical function: peptidyl-dipeptidase activity
Biological process: endocytosis involved in viral entry into host cell
Cellular component: membrane

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EC 3.4.17.23: Angiotensin-converting enzyme 2

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Systematic name:
-
Alternative Name(s):
  • ACE-2
  • ACE2
  • Angiotensin converting enzyme 2
  • Angiotensin converting enzyme-2
  • HACE2
  • Tmem27

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01601
Domain description: Coronavirus spike glycoprotein S2
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7wk6 contains 1 copy of Pfam domain PF01601 (Coronavirus spike glycoprotein S2) in Spike glycoprotein. Showing 1 copy in chain A [auth E] (this domain is out of the observed residue ranges!).

PF19209
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7wk6 contains 1 copy of Pfam domain PF19209 (Coronavirus spike glycoprotein S1, C-terminal) in Spike glycoprotein. Showing 1 copy in chain A [auth E] (this domain is out of the observed residue ranges!).

PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7wk6 contains 1 copy of Pfam domain PF09408 (Betacoronavirus spike glycoprotein S1, receptor binding) in Spike glycoprotein. Showing 1 copy in chain A [auth E].

PF16451
Domain description: Betacoronavirus-like spike glycoprotein S1, N-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7wk6 contains 1 copy of Pfam domain PF16451 (Betacoronavirus-like spike glycoprotein S1, N-terminal) in Spike glycoprotein. Showing 1 copy in chain A [auth E].

PF01401
Domain description: Angiotensin-converting enzyme
Occurring in:
  1. Processed angiotensin-converting enzyme 2
The deposited structure of PDB entry 7wk6 contains 1 copy of Pfam domain PF01401 (Angiotensin-converting enzyme) in Processed angiotensin-converting enzyme 2. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR001548
Domain description: Peptidase M2, peptidyl-dipeptidase A
Occurring in:
  1. Processed angiotensin-converting enzyme 2
IPR043473
Domain description: Spike glycoprotein S2 superfamily, coronavirus
Occurring in:
  1. Spike glycoprotein
IPR018548
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
Occurring in:
  1. Spike glycoprotein
IPR032500
Domain description: Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
Occurring in:
  1. Spike glycoprotein
IPR012473
Domain description: Fibritin C-terminal
Occurring in:
  1. Spike glycoprotein
IPR044874
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 2
Occurring in:
  1. Spike glycoprotein
IPR044873
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 1
Occurring in:
  1. Spike glycoprotein
IPR002552
Domain description: Spike glycoprotein S2, coronavirus
Occurring in:
  1. Spike glycoprotein
IPR043607
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Spike glycoprotein
IPR036326
Domain description: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Occurring in:
  1. Spike glycoprotein
IPR043002
Domain description: Spike glycoprotein, N-terminal domain superfamily
Occurring in:
  1. Spike glycoprotein
IPR044341
Domain description: Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like
Occurring in:
  1. Spike glycoprotein
IPR042578
Domain description: Spike glycoprotein, betacoronavirus
Occurring in:
  1. Spike glycoprotein

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