› 7wlk

Electron Microscopy
3.6Å resolution

CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB)

Released:
DOI: 10.2210/pdb7wlk/pdb
PDB entry 7wlk coloured by chain, front view.
PDB entry 7wlk coloured by chain, side view.
PDB entry 7wlk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure, gating, and pharmacology of human CaV3.3 channel.
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
OpenAccess logo Nat Commun 13 2084 (2022)
PMID: 35440630
Related structures: EMD-32586

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576530 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent T-type calcium channel subunit alpha-1I Chain: A
Molecule details ›
Chain: A
Length: 2223 amino acids
Theoretical weight: 245.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9P0X4 (Residues: 1-2223; Coverage: 100%)
Gene names: CACNA1I, KIAA1120
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand 7TB 1 x 7TB
Ligand 3PE 6 x 3PE
Ligand CA 2 x CA
Ligand Y01 6 x Y01
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-32586
Expression system: Homo sapiens

Quick links

Citations

8 citation in other articles

A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels.
Spafford JD. (2023)
7 more

1 mention without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)