› 7wmd

X-ray diffraction
2Å resolution

PQQ-dependent alcohol dehydrogenase detoxifying DON

Released:
DOI: 10.2210/pdb7wmd/pdb
PDB entry 7wmd coloured by chain, front view.
PDB entry 7wmd coloured by chain, side view.
PDB entry 7wmd coloured by chain, top view.
Source organism: Devosia albogilva
Primary publication:
Structure-Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification.
Yang H, Yan R, Li Y, Lu Z, Bie X, Zhao H, Lu F, Chen M
J Agric Food Chem 70 6764-6774 (2022)
PMID: 35613468

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Quinone-dependent DON dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 579 amino acids
Theoretical weight: 61.91 KDa
Source organism: Devosia albogilva
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A6B8QJ68 (Residues: 20-598; Coverage: 100%)
Gene name: QDDH
Sequence domains: PQQ-like domain

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 110.539Å b: 90.536Å c: 57.294Å
α: 90° β: 103.81° γ: 90°
R-values:
R R work R free
0.17 0.168 0.217
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review.
Sun et al. (2023)
1 more

1 mention without citation

Four PQQ-Dependent Alcohol Dehydrogenases Responsible for the Oxidative Detoxification of Deoxynivalenol in a Novel Bacterium Ketogulonicigenium vulgare D3_3 Originated from the Feces of Tenebrio molitor Larvae.
Wang et al. (2023)