7wmv

Electron Microscopy
3.2Å resolution

Structure of human SGLT1-MAP17 complex bound with LX2761

Released:
Source organism: Homo sapiens
Primary publication:
Structural mechanism of SGLT1 inhibitors.
Nat Commun 13 6440 (2022)
PMID: 36307403
Related structures: EMD-32617

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-146804 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium/glucose cotransporter 1 Chain: A
Molecule details ›
Chain: A
Length: 664 amino acids
Theoretical weight: 73.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13866 (Residues: 1-664; Coverage: 100%)
Gene names: NAGT, SGLT1, SLC5A1
Sequence domains: Sodium:solute symporter family
PDZK1-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 12.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13113 (Residues: 1-114; Coverage: 100%)
Gene names: MAP17, PDZK1IP1
Sequence domains: Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-32617
Expression system: Homo sapiens