› 7wn0

Electron Microscopy
3.64Å resolution

Structure of PfENT1(Y190A) in complex with nanobody 19

Released:
DOI: 10.2210/pdb7wn0/pdb
PDB entry 7wn0 coloured by chain, front view.
PDB entry 7wn0 coloured by chain, side view.
PDB entry 7wn0 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1.
Wang C, Yu L, Zhang J, Zhou Y, Sun B, Xiao Q, Zhang M, Liu H, Li J, Li J, Luo Y, Xu J, Lian Z, Lin J, Wang X, Zhang P, Guo L, Ren R, Deng D
OpenAccess logo Nat Commun 14 1727 (2023)
PMID: 36977719
Related structures: EMD-32618

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226975 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleoside transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 422 amino acids
Theoretical weight: 47.58 KDa
Source organism: Plasmodium falciparum
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IDM6 (Residues: 1-422; Coverage: 100%)
Gene names: NT1, PF3D7_1347200
nanobody19 Chain: B
Molecule details ›
Chain: B
Length: 123 amino acids
Theoretical weight: 13.18 KDa
Source organism: Vicugna pacos
Expression system: Bacillus subtilis

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.64Å
Relevant EMDB volumes: EMD-32618
Expression systems:
  • Spodoptera frugiperda
  • Bacillus subtilis

Quick links

Citations

1 review citation

Critical interdependencies between Plasmodium nutrient flux and drugs.
Henshall et al. (2023)
2 other articles