› 7wnx

Electron Microscopy
3.36Å resolution

Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs

Released:
DOI: 10.2210/pdb7wnx/pdb
PDB entry 7wnx coloured by chain, front view.
PDB entry 7wnx coloured by chain, side view.
PDB entry 7wnx coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3.
Hu T, Yang X, Liu F, Sun S, Xiong Z, Liang J, Yang X, Wang H, Yang X, Guddat LW, Yang H, Rao Z, Zhang B
Structure 30 1395-1402.e4 (2022)
PMID: 35981536
Related structures: EMD-32634

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trehalose monomycolate exporter MmpL3 Chain: A
Molecule details ›
Chain: A
Length: 1018 amino acids
Theoretical weight: 110.06 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QP27 (Residues: 1-1013; Coverage: 100%)
Gene names: MSMEG_0250, MSMEI_0243, mmpL3
Sequence domains: MMPL family

Ligands and Environments

1 bound ligand:
Ligand 1I2 1 x 1I2
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-32634
Expression system: Mycolicibacterium smegmatis MC2 155

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Citations

1 review citation

Recent advances in mycobacterial membrane protein large 3 inhibitor drug design for mycobacterial infections.
North et al. (2023)
1 other article