› 7wo5

Electron Microscopy
3.45Å resolution

SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 trimer)

Released:
DOI: 10.2210/pdb7wo5/pdb
PDB entry 7wo5 coloured by chain, front view.
PDB entry 7wo5 coloured by chain, side view.
PDB entry 7wo5 coloured by chain, top view.
Source organisms:
Primary publication:
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer.
Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T, Chen Z, Lan F, Sun L
OpenAccess logo J Virol e0048022 (2022)
PMID: 35924918
Related structures: EMD-32639

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225387 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.26 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
mAb15 VH Chains: D, F, H
Molecule details ›
Chains: D, F, H
Length: 225 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
mAb15 VL Chains: E, G, I
Molecule details ›
Chains: E, G, I
Length: 218 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 45 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.45Å
Relevant EMDB volumes: EMD-32639
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Monoclonal antibody therapies against SARS-CoV-2.
Focosi et al. (2022)
3 more

1 mention without citation

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer.
Zhan et al. (2022)