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Structure of Active-mutEP

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: membrane

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EC 3.4.21.9: Enteropeptidase

Reaction catalysed:
Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.
Alternative Name(s):
  • Enterokinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Enteropeptidase catalytic light chain
The deposited structure of PDB entry 7wqz contains 1 copy of Pfam domain PF00089 (Trypsin) in Enteropeptidase catalytic light chain. Showing 1 copy in chain B.

PF15494
Domain description: Scavenger receptor cysteine-rich domain
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
The deposited structure of PDB entry 7wqz contains 1 copy of Pfam domain PF15494 (Scavenger receptor cysteine-rich domain) in Enteropeptidase non-catalytic heavy chain. Showing 1 copy in chain A.

PF00057
Domain description: Low-density lipoprotein receptor domain class A
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
The deposited structure of PDB entry 7wqz contains 1 copy of Pfam domain PF00057 (Low-density lipoprotein receptor domain class A) in Enteropeptidase non-catalytic heavy chain. Showing 1 copy in chain A.

PF00431
Domain description: CUB domain
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
The deposited structure of PDB entry 7wqz contains 1 copy of Pfam domain PF00431 (CUB domain) in Enteropeptidase non-catalytic heavy chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002172
Domain description: Low-density lipoprotein (LDL) receptor class A repeat
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Enteropeptidase catalytic light chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Enteropeptidase catalytic light chain
IPR000859
Domain description: CUB domain
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Enteropeptidase catalytic light chain
IPR036772
Domain description: SRCR-like domain superfamily
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR035914
Domain description: Spermadhesin, CUB domain superfamily
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Enteropeptidase catalytic light chain
IPR001190
Domain description: SRCR domain
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR023415
Domain description: Low-density lipoprotein (LDL) receptor class A, conserved site
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain
IPR036055
Domain description: LDL receptor-like superfamily
Occurring in:
  1. Enteropeptidase non-catalytic heavy chain

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