Function and Biology Details
Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M2, peptidyl-dipeptidase A
- Spike glycoprotein S2 superfamily, coronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
- Fibritin C-terminal
- Spike glycoprotein S2, coronavirus, heptad repeat 2
- Spike glycoprotein S2, coronavirus, heptad repeat 1
- Spike glycoprotein S2, coronavirus
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144660 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein
Molecule details ›
Chains: A, B, C
Length: 1243 amino acids
Theoretical weight: 138.04 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 1243 amino acids
Theoretical weight: 138.04 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
- Canonical:
P0DTC2 (Residues: 15-210, 211-211, 215-1208; Coverage: 94%)
Sequence domains:
Processed angiotensin-converting enzyme 2
Molecule details ›
Chain: D
Length: 598 amino acids
Theoretical weight: 69.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 598 amino acids
Theoretical weight: 69.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q8R0I0 (Residues: 18-615; Coverage: 76%)
Sequence domains: Angiotensin-converting enzyme
