› 7wsm

Electron Microscopy
3.25Å resolution

Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in lipid nanodiscs

Released:
DOI: 10.2210/pdb7wsm/pdb
PDB entry 7wsm coloured by chain, front view.
PDB entry 7wsm coloured by chain, side view.
PDB entry 7wsm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human glucose transporter GLUT4.
Yuan Y, Kong F, Xu H, Zhu A, Yan N, Yan C
OpenAccess logo Nat Commun 13 2671 (2022)
PMID: 35562357
Related structures: EMD-32760

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147019 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 2, facilitated glucose transporter member 4 Chain: A
Molecule details ›
Chain: A
Length: 520 amino acids
Theoretical weight: 56.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14672 (Residues: 1-509; Coverage: 100%)
Gene names: GLUT4, SLC2A4
Sequence domains: Sugar (and other) transporter

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand 5RH 1 x 5RH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.25Å
Relevant EMDB volumes: EMD-32760
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer.
Choi et al. (2022)
1 more

3 mentions without citation

Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5.
McComas et al. (2023)
2 more