› 7wsv

Electron Microscopy
4.5Å resolution

Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc

Released:
DOI: 10.2210/pdb7wsv/pdb
PDB entry 7wsv coloured by chain, front view.
PDB entry 7wsv coloured by chain, side view.
PDB entry 7wsv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal 15 eabg6941 (2022)
PMID: 35133866
Related structures: EMD-32768

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pannexin-1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 407 amino acids
Theoretical weight: 45.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RD7 (Residues: 21-426; Coverage: 95%)
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Sequence domains: Innexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-32768
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Pannexin1 channels-a potential therapeutic target in inflammation.
Rusiecka et al. (2022)
2 more