› 7wvv

Electron Microscopy
2.9Å resolution

Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2

Released:
DOI: 10.2210/pdb7wvv/pdb
PDB entry 7wvv coloured by chain, front view.
PDB entry 7wvv coloured by chain, side view.
PDB entry 7wvv coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin.
Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B
OpenAccess logo Nat Commun 13 1775 (2022)
PMID: 35365641
Related structures: EMD-32859

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-276016 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
FME-LEU-PHE-ILE-ILE Chain: L
Molecule details ›
Chain: L
Length: 5 amino acids
Theoretical weight: 664 Da
Source organism: Homo sapiens
Expression system: Not provided
N-formyl peptide receptor 2; Soluble cytochrome b562 Chain: R
Molecule details ›
Chain: R
Length: 513 amino acids
Theoretical weight: 56.71 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
  • Canonical: P25090 (Residues: 2-347; Coverage: 99%)
Gene names: FPR2, FPRH1, FPRL1, LXA4R, cybC
Sequence domains:
Guanine nucleotide-binding protein G(i) subunit alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 40.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04899 (Residues: 1-355; Coverage: 100%)
Gene names: GNAI2, GNAI2B
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Molecule details ›
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand FME 1 x FME

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-32859
Expression systems:
  • Not provided
  • Spodoptera frugiperda

Quick links

Citations

4 review citations

Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation.
Chen et al. (2023)
3 more

3 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
2 more