› 7wvy

Electron Microscopy
3Å resolution

Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2

Released:
DOI: 10.2210/pdb7wvy/pdb
PDB entry 7wvy coloured by chain, front view.
PDB entry 7wvy coloured by chain, side view.
PDB entry 7wvy coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin.
Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B
OpenAccess logo Nat Commun 13 1775 (2022)
PMID: 35365641
Related structures: EMD-32862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138245 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Amyloid-beta protein 42 Chain: L
Molecule details ›
Chain: L
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)
N-formyl peptide receptor 2; Soluble cytochrome b562 Chain: R
Molecule details ›
Chain: R
Length: 513 amino acids
Theoretical weight: 56.71 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
  • Canonical: P25090 (Residues: 2-347; Coverage: 99%)
Gene names: FPR2, FPRH1, FPRL1, LXA4R, cybC
Sequence domains:
Guanine nucleotide-binding protein G(i) subunit alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 40.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04899 (Residues: 1-355; Coverage: 100%)
Gene names: GNAI2, GNAI2B
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Molecule details ›
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-32862
Expression systems:
  • Not provided
  • Spodoptera frugiperda

Quick links

Citations

3 review citations

Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
Lee et al. (2023)
2 more

1 mention without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)