› 7x06

Electron Microscopy
3.1Å resolution

CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with UDP

Released:
DOI: 10.2210/pdb7x06/pdb
PDB entry 7x06 coloured by chain, front view.
PDB entry 7x06 coloured by chain, side view.
PDB entry 7x06 coloured by chain, top view.
Source organism: Phytophthora sojae strain P6497
Primary publication:
Structural basis for directional chitin biosynthesis.
Chen W, Cao P, Liu Y, Yu A, Wang D, Chen L, Sundarraj R, Yuchi Z, Gong Y, Merzendorfer H, Yang Q
OpenAccess logo Nature (2022)
PMID: 36131020
Related structures: EMD-32918

Function and Biology Details

Reaction catalysed: 
UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124468 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitin synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 913 amino acids
Theoretical weight: 103.15 KDa
Source organism: Phytophthora sojae strain P6497
Expression system: Homo sapiens
UniProt:
  • Canonical: G4Z2L3 (Residues: 1-913; Coverage: 100%)
Gene names: CHS1, PHYSODRAFT_557500
Sequence domains: Chitin synthase

Ligands and Environments

2 bound ligands:
Ligand UDP 2 x UDP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-32918
Expression system: Homo sapiens

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Citations

4 review citations

Chitin Biosynthesis in Aspergillus Species.
Brauer et al. (2023)
3 more