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Cryo-EM structure of non gastric H,K-ATPase alpha2 K794S in (2K+)E2-AlF state

Electron Microscopy
3Å resolution
PDB entry 7x22 coloured by chain, front view.
PDB entry 7x22 coloured by chain, side view.
PDB entry 7x22 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Potassium-transporting ATPase alpha chain 2 and Sodium/potassium-transporting ATPase subunit beta-1
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Multimeric state: hetero dimer
Accessible surface area: 54764.84 Å2
Buried surface area: 12315.64 Å2
Dissociation area: 2,595.33 Å2
Dissociation energy (ΔGdiss): 22.19 kcal/mol
Dissociation entropy (TΔSdiss): 14.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139526

Macromolecules

Potassium-transporting ATPase alpha chain 2
Chain: A
Length: 986 amino acids
Theoretical weight: 109.04 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P54708 (Residues: 53-1036; Coverage: 95%)
Gene names: Atp12a, Atp1al1
Pfam:
InterPro:
Potassium-transporting ATPase alpha chain 2 in PDB entry 7x22, assembly 1, front view.
Potassium-transporting ATPase alpha chain 2 in PDB entry 7x22, assembly 1, side view.
Potassium-transporting ATPase alpha chain 2 in PDB entry 7x22, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P54708  
1986100200300400500600700800900
 
500GMDLDDHRLSNTELEQKYGTNIIQGLSSVRATELLARDGPNTLTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEIEHFVHIVAGVAVSIGIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRTVVGDASETALLKFSEVILGDVMGIRKRNHKVAEIPFNSTNKFQLSIHETEDPNNKRFLVVMKGAPERILEKCSTIMINGQEQPLDKSSADSFHTAYMELGGLGERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLTNYQEIVFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTSNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVAWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMIQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGLGSVPALSFTMLRVQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
UniProt
P54708
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Sodium/potassium-transporting ATPase subunit beta-1
Chain: B
Length: 324 amino acids
Theoretical weight: 37.52 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P07340 (Residues: 1-304; Coverage: 100%)
Gene name: Atp1b1
Pfam: Sodium / potassium ATPase beta chain
InterPro:
Sodium/potassium-transporting ATPase subunit beta-1 in PDB entry 7x22, assembly 1, front view.
Sodium/potassium-transporting ATPase subunit beta-1 in PDB entry 7x22, assembly 1, side view.
Sodium/potassium-transporting ATPase subunit beta-1 in PDB entry 7x22, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P07340  
132450100150200250300
 
100200300MGDYKDDDDKSSGENLYFQGMARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCSGLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
UniProt
P07340
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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