› 7x25

Electron Microscopy
2.49Å resolution

MERS-CoV spike complex with S41 neutralizing antibody Fab Class4 (2u1d RBD with 3Fab)

Released:
DOI: 10.2210/pdb7x25/pdb
PDB entry 7x25 coloured by chain, front view.
PDB entry 7x25 coloured by chain, side view.
PDB entry 7x25 coloured by chain, top view.
Source organisms:
Primary publication:
Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Zhang S, Jia W, Zeng J, Li M, Wang Z, Zhou H, Zhang L, Wang X
OpenAccess logo Front Microbiol 13 988298 (2022)
PMID: 36246239
Related structures: EMD-32958

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224848 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
antibody S41 heavy chain Chains: A, E, H
Molecule details ›
Chains: A, E, H
Length: 221 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
antibody S41 light chain Chains: C, F, K
Molecule details ›
Chains: C, F, K
Length: 212 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike glycoprotein Chains: G, I, J
Molecule details ›
Chains: G, I, J
Length: 1347 amino acids
Theoretical weight: 148.57 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: K9N5Q8 (Residues: 1-1290; Coverage: 95%)
Gene names: 3, S
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.49Å
Relevant EMDB volumes: EMD-32958
Expression systems:
  • Homo sapiens
  • Trichoplusia ni

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