› 7xbd

Electron Microscopy
3.11Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-224890 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Galanin receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 41.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43603 (Residues: 1-387; Coverage: 100%)
Gene names: GALNR2, GALR2
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(q) subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 246 amino acids
Theoretical weight: 28.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: D
Molecule details ›
Chain: D
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
scFv16 Chain: E
Molecule details ›
Chain: E
Length: 257 amino acids
Theoretical weight: 27.47 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
Galanin Chain: F
Molecule details ›
Chain: F
Length: 30 amino acids
Theoretical weight: 3.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P22466 (Residues: 33-62; Coverage: 29%)
Gene names: GAL, GAL1, GALN, GLNN
Sequence domains: Galanin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.11Å
Relevant EMDB volumes: EMD-33103
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

1 mention without citation

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Heo et al. (2022)