› 7xdd

Electron Microscopy
2.93Å resolution

Cryo-EM structure of EDS1 and PAD4

Released:
DOI: 10.2210/pdb7xdd/pdb
PDB entry 7xdd coloured by chain, front view.
PDB entry 7xdd coloured by chain, side view.
PDB entry 7xdd coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity.
Huang S, Jia A, Song W, Hessler G, Meng Y, Sun Y, Xu L, Laessle H, Jirschitzka J, Ma S, Xiao Y, Yu D, Hou J, Liu R, Sun H, Liu X, Han Z, Chang J, Parker JE, Chai J
Science 377 eabq3297 (2022)
PMID: 35857645
Related structures: EMD-33144

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193415 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lipase-like PAD4 Chain: A
Molecule details ›
Chain: A
Length: 538 amino acids
Theoretical weight: 60.69 KDa
Source organism: Arabidopsis thaliana
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9S745 (Residues: 4-541; Coverage: 99%)
Gene names: At3g52430, EDS9, F22O6.190, PAD4
Sequence domains:
Protein EDS1 Chain: B
Molecule details ›
Chain: B
Length: 623 amino acids
Theoretical weight: 71.78 KDa
Source organism: Arabidopsis thaliana
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9SU72 (Residues: 1-623; Coverage: 100%)
Gene names: At3g48090, EDS1, EDS1-90, EDS1A, T17F15.40
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.93Å
Relevant EMDB volumes: EMD-33144
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants.
Maekawa et al. (2023)
15 more

1 mention without citation

A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4.
Voss et al. (2023)