› 7xf5

Electron Microscopy
3.9Å resolution

Full length human CLC-2 channel in apo state

Released:
DOI: 10.2210/pdb7xf5/pdb
PDB entry 7xf5 coloured by chain, front view.
PDB entry 7xf5 coloured by chain, side view.
PDB entry 7xf5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Ma T, Wang L, Chai A, Liu C, Cui W, Yuan S, Wing Ngor Au S, Sun L, Zhang X, Zhang Z, Lu J, Gao Y, Wang P, Li Z, Liang Y, Vogel H, Wang YT, Wang D, Yan K, Zhang H
Nat Commun 14 3424- (2023)
Related structures: EMD-33169

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 898 amino acids
Theoretical weight: 98.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51788 (Residues: 1-898; Coverage: 100%)
Gene name: CLCN2
Sequence domains: Voltage gated chloride channel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-33169
Expression system: Homo sapiens

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