› › Function and Biology

Human renin in complex with compound2

Source organism: Homo sapiens
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

Quick links

EC 3.4.23.15: Renin

Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Alternative Name(s):
  • Angiotensin-forming enzyme
  • Angiotensinogenase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Renin
The deposited structure of PDB entry 7xgo contains 2 copies of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Renin. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001461
Domain description: Aspartic peptidase A1 family
Occurring in:
  1. Renin
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Renin
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Renin
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Renin
IPR034135
Domain description: Renin-like domain
Occurring in:
  1. Renin

Quick links