› 7xh8

Electron Microscopy
2.99Å resolution

The structure of ZCB11 Fab against SARS-CoV-2 Omicron Spike

Released:
DOI: 10.2210/pdb7xh8/pdb
PDB entry 7xh8 coloured by chain, front view.
PDB entry 7xh8 coloured by chain, side view.
PDB entry 7xh8 coloured by chain, top view.
Source organisms:
Primary publication:
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge.
Zhou B, Zhou R, Tang B, Chan JF, Luo M, Peng Q, Yuan S, Liu H, Mok BW, Chen B, Wang P, Poon VK, Chu H, Chan CC, Tsang JO, Chan CC, Au KK, Man HO, Lu L, To KK, Chen H, Yuen KY, Dang S, Chen Z
OpenAccess logo Nat Commun 13 3589 (2022)
PMID: 35739114
Related structures: EMD-33191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210026 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 1205 amino acids
Theoretical weight: 133.91 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-210, 211-211, 215-1208; Coverage: 94%)
Gene names: 2, S
Sequence domains:
The heavy chain of ZCB11 antibody Chain: B
Molecule details ›
Chain: B
Length: 222 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
The light chain of ZCB11 antibody Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.99Å
Relevant EMDB volumes: EMD-33191
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Cell and Animal Models for SARS-CoV-2 Research.
Bestion et al. (2022)
10 other articles

3 mentions without citation

A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies.
Chatterjee et al. (2023)
2 more