7xhv

X-ray diffraction
4Å resolution

Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-215671 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Aryl hydrocarbon receptor nuclear translocator Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 30.94 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53762 (Residues: 82-360; Coverage: 35%)
Gene name: Arnt
Sequence domains:
Neuronal PAS domain-containing protein 4 Chain: B
Molecule details ›
Chain: B
Length: 211 amino acids
Theoretical weight: 23.34 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8BGD7 (Residues: 1-205; Coverage: 26%)
Gene names: Npas4, Nxf
DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3') Chain: C
Molecule details ›
Chain: C
Length: 16 nucleotides
Theoretical weight: 5.03 KDa
DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3') Chain: D
Molecule details ›
Chain: D
Length: 16 nucleotides
Theoretical weight: 4.76 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 72.846Å b: 72.846Å c: 272.741Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.275 0.272 0.331
Expression system: Escherichia coli BL21(DE3)