› 7xkk

Electron Microscopy
3.2Å resolution

Human Cx36/GJD2 gap junction channel in detergents

Released:
DOI: 10.2210/pdb7xkk/pdb
PDB entry 7xkk coloured by chain, front view.
PDB entry 7xkk coloured by chain, side view.
PDB entry 7xkk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.
Lee SN, Cho HJ, Jeong H, Ryu B, Lee HJ, Kim M, Yoo J, Woo JS, Lee HH
OpenAccess logo Nat Commun 14 1347 (2023)
PMID: 36906653
Related structures: EMD-33256

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction delta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 332 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UKL4 (Residues: 1-321; Coverage: 100%)
Gene names: GJA9, GJD2
Sequence domains: Connexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-33256
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Diversity in connexin biology.
Lucaciu et al. (2023)
2 more