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Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state

Electron Microscopy
3.1Å resolution
PDB entry 7xlq coloured by chain, front view.
PDB entry 7xlq coloured by chain, side view.
PDB entry 7xlq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-dependent calcium channel
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Multimeric state: hetero trimer
Accessible surface area: 113650.86 Å2
Buried surface area: 13460.85 Å2
Dissociation area: 2,081.63 Å2
Dissociation energy (ΔGdiss): 2.07 kcal/mol
Dissociation entropy (TΔSdiss): 29.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156988

Macromolecules

Voltage-dependent R-type calcium channel subunit alpha-1E
Chain: A
Length: 2313 amino acids
Theoretical weight: 262.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15878 (Residues: 1-2313; Coverage: 100%)
Gene names: CACH6, CACNA1E, CACNL1A6
Pfam:
InterPro:
Voltage-dependent R-type calcium channel subunit alpha-1E in PDB entry 7xlq, assembly 1, front view.
Voltage-dependent R-type calcium channel subunit alpha-1E in PDB entry 7xlq, assembly 1, side view.
Voltage-dependent R-type calcium channel subunit alpha-1E in PDB entry 7xlq, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q15878  
123132004006008001,0001,2001,4001,6001,8002,0002,200
 
10002000
UniProt
Q15878
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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Voltage-dependent calcium channel subunit alpha-2/delta-1
Chain: D
Length: 1077 amino acids
Theoretical weight: 122.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 27-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Pfam:
InterPro:
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 7xlq, assembly 1, front view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 7xlq, assembly 1, side view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 7xlq, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P54289  
110771002003004005006007008009001,000
 
5001000
UniProt
P54289
PRO_0000005001
PRO_0000005002
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Voltage-dependent L-type calcium channel subunit beta-1
Chain: B
Length: 598 amino acids
Theoretical weight: 65.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02641 (Residues: 1-598; Coverage: 100%)
Gene names: CACNB1, CACNLB1
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit beta-1 in PDB entry 7xlq, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit beta-1 in PDB entry 7xlq, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit beta-1 in PDB entry 7xlq, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q02641  
159850100150200250300350400450500550
 
200400
UniProt
Q02641
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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