7xmf

Electron Microscopy
3.07Å resolution

Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for NaV1.7 inhibition by pore blockers.
Nat Struct Mol Biol (2022)
PMID: 36424527
Related structures: EMD-33295

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-130219 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2250 amino acids
Theoretical weight: 255.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15858 (Residues: 1-1988; Coverage: 99%)
  • Best match: Q15858-3 (Residues: 1-1977)
Gene names: NENA, SCN9A
Sequence domains:
Sodium channel regulatory subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 481 amino acids
Theoretical weight: 54.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain
Sodium channel regulatory subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 1-215; Coverage: 100%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-33295
Expression system: Homo sapiens