› 7xna

X-ray diffraction
2.65Å resolution

Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806

Released:
DOI: 10.2210/pdb7xna/pdb
PDB entry 7xna coloured by chain, front view.
PDB entry 7xna coloured by chain, side view.
PDB entry 7xna coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into ligand recognition and selectivity of somatostatin receptors.
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022)
PMID: 35739238

Function and Biology Details

Reaction catalysed: 
Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140765 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endo-1,4-beta-xylanase; Somatostatin receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.5 KDa
Source organisms: Expression system: Insecta environmental sample
UniProt:
  • Canonical: P30874 (Residues: 2-237, 244-359; Coverage: 95%)
  • Canonical: P09850 (Residues: 29-213; Coverage: 100%)
Gene names: SSTR2, xlnA
Sequence domains:
CYN 154806 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.18 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
4 modified residues:
Ligand PPN 1 x PPN
Ligand DCY 1 x DCY
Ligand DTR 1 x DTR
Ligand DTY 1 x DTY

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 42.15Å b: 85.21Å c: 163.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.29
Expression systems:
  • Insecta environmental sample
  • Not provided

Quick links

Citations

2 review citations

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications.
Feng et al. (2023)
1 more

2 mentions without citation

Identification of a Novel SSTR3 Full Agonist for the Treatment of Nonfunctioning Pituitary Adenomas.
Modena et al. (2023)
1 more