› 7xng

X-ray diffraction
2.35Å resolution

Crystal structure of CBP bromodomain liganded with Y08092(31g)

Released:
DOI: 10.2210/pdb7xng/pdb
PDB entry 7xng coloured by chain, front view.
PDB entry 7xng coloured by chain, side view.
PDB entry 7xng coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xiang Q, Zhang Y, Wang C, Song M, Xu Y

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 133 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand GI5 2 x GI5
Ligand GOL 1 x GOL
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2221
Unit cell:
a: 60.119Å b: 75.309Å c: 123.489Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.242
Expression system: Escherichia coli

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