› 7xni

Electron Microscopy
3.5Å resolution

human KCNQ1-CaM in apo state

Released:
DOI: 10.2210/pdb7xni/pdb
PDB entry 7xni coloured by chain, front view.
PDB entry 7xni coloured by chain, side view.
PDB entry 7xni coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
OpenAccess logo Proc Natl Acad Sci U S A 119 e2207067119 (2022)
PMID: 36763058
Related structures: EMD-33316

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144007 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, B, D, G
Molecule details ›
Chains: A, B, D, G
Length: 692 amino acids
Theoretical weight: 76.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51787 (Residues: 1-676; Coverage: 100%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains:
Calmodulin-3 Chains: C, E, F, H
Molecule details ›
Chains: C, E, F, H
Length: 177 amino acids
Theoretical weight: 19.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP25 (Residues: 1-149; Coverage: 100%)
Gene names: CALM3, CALML2, CAM3, CAMC, CAMIII
Sequence domains: EF-hand domain pair

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-33316
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Fundamental concepts of protein therapeutics and spacing in oncology: an updated comprehensive review.
Farasati Far et al. (2023)
7 other articles

1 mention without citation

Recent Advances in Computer-Aided Structure-Based Drug Design on Ion Channels.
Pliushcheuskaya et al. (2023)