› 7xnn

Electron Microscopy
2.5Å resolution

human KCNQ1-CaM-ML277-PIP2 complex in state B

Released:
DOI: 10.2210/pdb7xnn/pdb
PDB entry 7xnn coloured by chain, front view.
PDB entry 7xnn coloured by chain, side view.
PDB entry 7xnn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
OpenAccess logo Proc Natl Acad Sci U S A 119 e2207067119 (2022)
PMID: 36763058
Related structures: EMD-33319

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144007 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-3 Chains: A, D, F, H
Molecule details ›
Chains: A, D, F, H
Length: 177 amino acids
Theoretical weight: 19.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP25 (Residues: 1-149; Coverage: 100%)
Gene names: CALM3, CALML2, CAM3, CAMC, CAMIII
Sequence domains: EF-hand domain pair
Potassium voltage-gated channel subfamily KQT member 1 Chains: B, C, E, G
Molecule details ›
Chains: B, C, E, G
Length: 692 amino acids
Theoretical weight: 76.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51787 (Residues: 1-676; Coverage: 100%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand K 4 x K
Ligand I0S 4 x I0S
Ligand PIO 4 x PIO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-33319
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Recent Advances in Computer-Aided Structure-Based Drug Design on Ion Channels.
Pliushcheuskaya et al. (2023)
1 more

1 mention without citation

KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.
González-Garrido et al. (2024)