› 7xnv

Electron Microscopy
3.4Å resolution

Structurally hetero-junctional human Cx36/GJD2 gap junction channel in soybean lipids (C6 symmetry)

Released:
DOI: 10.2210/pdb7xnv/pdb
PDB entry 7xnv coloured by chain, front view.
PDB entry 7xnv coloured by chain, side view.
PDB entry 7xnv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.
Lee SN, Cho HJ, Jeong H, Ryu B, Lee HJ, Kim M, Yoo J, Woo JS, Lee HH
Nat Commun 14 1347 (2023)
PMID: 36906653
Related structures: EMD-33327

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction delta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 332 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UKL4 (Residues: 1-321; Coverage: 100%)
Gene names: GJA9, GJD2
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand MC3 114 x MC3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-33327
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Diversity in connexin biology.
Lucaciu et al. (2023)
1 other article