› 7xoe

Electron Microscopy
3.9Å resolution

Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state)

Released:
DOI: 10.2210/pdb7xoe/pdb
PDB entry 7xoe coloured by chain, front view.
PDB entry 7xoe coloured by chain, side view.
PDB entry 7xoe coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J
Sci Bull (Beijing) 68 3192-3206 (2023)
PMID: 37993332
Related structures: EMD-33346

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1293 amino acids
Theoretical weight: 142.82 KDa
Source organism: synthetic construct
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1255; Coverage: 98%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 21 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-33346
Expression system: Homo sapiens

Quick links

Citations

2 review citations

A Comprehensive Review on the Current Vaccines and Their Efficacies to Combat SARS-CoV-2 Variants.
Rabaan et al. (2022)
1 more