Function and Biology

Crystal structure of the human OX2R bound to the insomnia drug lemborexant.

Source organism: Homo sapiens
Biochemical function: orexin receptor activity
Biological process: feeding behavior
Cellular component: membrane

Sequence family

Pfam Protein family (Pfam)
PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. Orexin receptor type 2
The deposited structure of PDB entry 7xrr contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in Orexin receptor type 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. Orexin receptor type 2
IPR000204
Domain description: Orexin receptor family
Occurring in:
  1. Orexin receptor type 2
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. Orexin receptor type 2