› 7xsu

Electron Microscopy
3.4Å resolution

Cardiac sodium channel in complex with LqhIII

Released:
DOI: 10.2210/pdb7xsu/pdb
PDB entry 7xsu coloured by chain, front view.
PDB entry 7xsu coloured by chain, side view.
PDB entry 7xsu coloured by chain, top view.
Source organisms:
Entry authors: Jiang D, Catterall WA
Related structures: EMD-33435

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236013 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G protein/GFP fusion protein; Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1838 amino acids
Theoretical weight: 209.04 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P15389 (Residues: 1-1898; Coverage: 78%)
  • Canonical: B7UCZ6 (Residues: 512-750; Coverage: 32%)
Gene names: G, GFP, Scn5a
Sequence domains:
Alpha-like toxin Lqh3 Chain: B
Molecule details ›
Chain: B
Length: 67 amino acids
Theoretical weight: 7.07 KDa
UniProt:
  • Canonical: P56678 (Residues: 1-67; Coverage: 100%)
Sequence domains: Scorpion toxin-like domain

Ligands and Environments

4 bound ligands:
Ligand NAG 5 x NAG
Ligand BMA 1 x BMA
Ligand 6OU 6 x 6OU
Ligand 9Z9 1 x 9Z9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-33435
Expression system: Homo sapiens

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