› 7xt6

Electron Microscopy
3.63Å resolution

Structure of a membrane protein M3

Released:
DOI: 10.2210/pdb7xt6/pdb
PDB entry 7xt6 coloured by chain, front view.
PDB entry 7xt6 coloured by chain, side view.
PDB entry 7xt6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of two human B cell receptor isotypes.
Ma X, Zhu Y, Chen Y, Wang S, Yang D, Ma Z, Zhang A, Zhang F, Guo C, Huang Z
Science 377 880-885 (2022)
PMID: 35981028
Related structures: EMD-33440

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-134958 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
B-cell antigen receptor complex-associated protein alpha chain Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P11912 (Residues: 33-169; Coverage: 71%)
Gene names: CD79A, IGA, MB1
Sequence domains: Immunoglobulin domain
Immunoglobulin heavy constant mu Chains: B, D
Molecule details ›
Chains: B, D
Length: 364 amino acids
Theoretical weight: 40.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01871 (Residues: 109-472; Coverage: 77%)
Gene name: IGHM
Sequence domains: Immunoglobulin C1-set domain
B-cell antigen receptor complex-associated protein beta chain Chain: C
Molecule details ›
Chain: C
Length: 139 amino acids
Theoretical weight: 16.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P40259 (Residues: 44-182; Coverage: 69%)
Gene names: B29, CD79B, IGB
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.63Å
Relevant EMDB volumes: EMD-33440
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities.
Wang et al. (2023)
4 more

1 mention without citation

Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer.
Xiong et al. (2023)