› 7xuo

Electron Microscopy
3.6Å resolution

Structure of ATP7B C983S/C985S/D1027A mutant with cisplatin in presence of ATOX1

Released:
DOI: 10.2210/pdb7xuo/pdb
PDB entry 7xuo coloured by chain, front view.
PDB entry 7xuo coloured by chain, side view.
PDB entry 7xuo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the human Wilson disease copper transporter ATP7B.
Yang GM, Xu L, Wang RM, Tao X, Zheng ZW, Chang S, Ma D, Zhao C, Dong Y, Wu S, Guo J, Wu ZY
Cell Rep 42 112417 (2023)
PMID: 37074913
Related structures: EMD-33476

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 1507 amino acids
Theoretical weight: 162.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35670 (Residues: 1-1465; Coverage: 100%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PT 1 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-33476
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Targeting cuproplasia and cuproptosis in cancer.
Tang et al. (2024)
2 more