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Crystal structure of RPA70N-BLMp2 fusion

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: DNA replication
Cellular component: nucleus

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF04057
Domain description: Replication factor-A protein 1, N-terminal domain
Occurring in:
  1. RecQ-like DNA helicase BLM; Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
The deposited structure of PDB entry 7xuw contains 1 copy of Pfam domain PF04057 (Replication factor-A protein 1, N-terminal domain) in RecQ-like DNA helicase BLM. Showing 1 copy in chain A.

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